The N.F.L. has two remaining unbeaten teams: the reliably talented New England Patriots and the underdogs in San Francisco.

Through six weeks of the season, Russell Wilson is playing the best football of his career and a leading candidate for NFL MVP. On Sunday, Wilson put together yet another near-flawless performance, leading the Seattle Seahawks to a 32-28 comeback victory over…

Lamar Jackson rolled over Cincinnati, the 49ers stayed undefeated, and the Jets, Redskins and Cardinals all, somehow, won.

49ers are undeniably team to beat in NFC West Niners Wire Robert Saleh: 49ers Defense is 'Relentless' San Francisco 49ers 49ers defense smothers Rams in 20-7 win NBCSports.com Jimmy Garoppolo Keeps the 49ers Undefeated! | 2019 NFL Highlights NFL 49ers at Rams…

In 2018, the San Francisco 49ers were an injury-ravaged mess of a football team that won just four games and finished 13th in the NFL in total defense and 28th in scoring defense...

The San Francisco 49ers travel to LA this Sunday where they'll face a ticked-off Rams team that can't wait to deliver them their first loss.

Richard Sherman accused Baker Mayfield of refusing to shake his hand before kickoff of the Browns-49ers game on Monday night. Video later appeared to show Mayfield and Sherman shaking hands at midfield, making Sherman's initial claim quite confusing. While Sh…

The San Francisco 49ers are 4-0 for the first time since 1990, and the Jimmy Garoppolo vs. Joe Montana debate is raging on NFL Twitter.

The San Francisco 49ers could be without a key piece of their offensive attack for an extended period. Fullback Kyle Juszczyk was initially diagnosed with an MCL injury sustained Monday night, per Tom Pelissero.

The San Francisco 49ers announced Tuesday afternoon that fullback Kyle Juszczyk will be out 4 to 6 weeks after suffered an MCL sprain during Monday's 31-3 shellacking of the Browns

The San Francisco 49ers could be without a key piece of their offensive attack for an extended period. Fullback Kyle Juszczyk was initially diagnosed with an MCL injury sustained Monday night, per Tom Pelissero.

Against the undefeated San Francisco 49ers on Monday night, quarterback Baker Mayfield had his worst game of the season. Mayfield's goal now is to find consistency where there's been none.

"What are the 49ers?" The rhetorical question was posed by ESPN play-by-play man Joe Tessitore midway through the third quarter of Monday night's 31-3 San Francisco victory over the Cleveland Browns...

San Francisco (4-0) secured its fourth win in as many tries by routing the Cleveland Browns (2-3), 31-3, on "Monday Night Football" in Week 5.

San Francisco 49ers defensive tackle D.J. Jones stepped away from his pregame preparation on Monday to propose to his girlfriend.

Richard Sherman doesn't think the grass is greener outside of San Francisco. "I think we're good with what we have," the 49ers cornerback said Thursday, according to NBC Sports ...

Jaguars linebacker Myles Jack was ejected Sunday against the Chiefs for throwing a punch at WR Demarcus Robinson; 49ers LB Kwon Alexander was DQ'd for a helmet-to-helmet hit.

After suffering a significant ankle sprain early in training camp, 49ers rookie defensive end Nick Bosa is slated to play in Week 1, according to NFL Network Insider Ian Rapoport.

Colin Kaepernick ’s still got it if video of his latest workout is any indication. The former San Francisco 49ers quarterback shared a video of his workout with Cleveland Browns wide receiver Odell Beckham Jr...

Jones leads Chargers past 49ers 27-24 in preseason finale

Jimmy Garoppolo exorcised his demons at Arrowhead Stadium on Saturday night with 188 yards, one touchdown and no interceptions on 14-of-20 passing in the San Francisco 49ers' 27-17 win over the Kansas City Chiefs...

While most of the NFL world loves the preseason because it builds anticipation for the start of the real games, it's also a nerve-wracking period for players fighting to make a team's roster...

Identifying and organizing the top 100 players in 49ers history.

Jay-Z was shocked that his involvement with the NFL was being interpreted by some as an affront to Colin Kaepernick.

Free-agent wide receiver Michael Crabtree has signed a one-year contract with the Arizona Cardinals , the team announced Wednesday night...

RT @RealMamaEagle: The Eagles have talked WAY less about losing the Super Bowl than the 49ers have talked about losing the title game. In…

RT @SDNiner49: Me laughing at the 49ers after trading Trey Lance and paying Brock Purdy $200M guaranteed with no Super Bowl wins, with the…

Which team wins: — Ravens offense + Patriots defense OR — 49ers offense + Cardinals defense

NFL Ravens, Patriots,49ers, Chargers,Rams NBA OKC,Miami, Houston, Phoenix, Washington MLB Toronto, Miami, Tampa Bay, Houston, Washington NHL Edmonton, Winnipeg, Toronto,Ottawa, Arizona https://t.co/wWkEc6nqRN

My Official NFC West Predictions 1. 49ers - 11-6 2. Seahawks - 10-7 3. Rams - 7-10 4. Cardinals - 3-14

No, the 89 49ers are legitimately the best team in NFL History. no doubt. https://t.co/5PJ6DJYV3c

I found the source of the Trey Lance Trade rumors!!!! @49ers https://t.co/OzYiCJ5SpY

RT @LombardiHimself: Saying the 49ers “don’t have a quarterback” is comically incorrect. They’re returning one of the NFL’s highest-rated…

RT @ryanghensley: I have opinions on which QB has potential to be that guy, but honestly, I don’t care who it is. The 49ers need one of the…

RT @thewaynebreezie: Roger Craig is a Semifinalist for the Hall of Fame C/O 2024. #49ers #NFL #FTTB https://t.co/IbDlBXtfvS

RT @b1gotfans: If Marshon Lattimore played for the 49ers people would call him the best CB to ever play the game

The 49ers KNEW They COULDN'T Win This Game! #shorts https://t.co/NVaQiWpiTf via @YouTube

Never EVER bet against Maya Moore! Lynx would take them for sure. If Maya didn't step away from the game she would currently be in the GOAT debate EASILY and she's still only 34. #WNBA #WBB https://t.co/9RjseGVFXr

I will forever die on the hill that Aiyuk is the most talented WR in that 49ers WR room...just needs to put it together all the way. I have him in the same realm as a DJ Moore, AJ Brown, Olave, Wilson. Will 2023 finally be the year for the Aiyuk explosion? I sure hope so! #FTTB https://t.co/RqKew13QRK

RT @EliotShorrParks: The 49ers have to be the most overrated “contender” the NFL has had going into a season in a very long time

RT @49ers_Access: Executives, Players, Scouts and Coaches ranked #49ers Nick Bosa the best edge rusher in the NFL Myles Garrett and Micah…

Eagles News: Deebo Samuel leaves interview after being asked about his sore loser comments https://t.co/8AeiZKWUFL

RT @OurSf49ers: The #49ers have announced open training camp dates: Wednesday, July 26 Thursday, July 27 Sunday, July 30 Monday, July 31 T…

ah yes, the respectable, high character 49ers fandom https://t.co/EvJjqNO9h4

PODCAST: What happened with the 49ers this offseason? https://t.co/QnqLA87jQd

Here are a few stories from the last week for Cardinals fans to know about the 49ers, one of Arizona’s division rivals. https://t.co/2uouQxjmJX

RT @MySportsUpdate: Top selling NFL jerseys in June: 1) Jalen Hurts, Eagles 2) Aaron Rodgers, Jets 3) Micah Parsons, Cowboys 4) Patrick Ma…

RT @4marfanz: #FreeContest #49ersSwag Okay #NinerFam, let's have some fun! What two team are going to the #SuperBowl this year? Winner…

RT @FinessedBuckets: When you draw the 49ers in the playoffs for a 3rd straight year

RT @TedH6: The 49ers' QB controversy: Why Purdy was best QB in 2022, but still 3rd string to start? Brian Renick @brenick77 joins TTB Tod…

RT @JoePops_: @NFL_DovKleiman @CBSSportsRadio @ZachGelb 49ers fans and players alike are the SOFTEST people on the face of the planet

49ers WR Deebo Samuel hangs up on radio host after questions about his Eagles comments #NFL #SchwartziesSports https://t.co/a2d1vjFMmc

RT @Bambamlld: Video evidence, that these two, are Deja Vu for Kyle Shanahan and Niner Fans. #49ers #BrockPurdy #JimmyGaroppolo #Dopplegang…

RT @TedH6: The 49ers' QB controversy: Why Purdy was best QB in 2022, but still 3rd string to start? Brian Renick @brenick77 joins TTB Tod…

RT @EliotShorrParks: The 49ers have to be the most overrated “contender” the NFL has had going into a season in a very long time

The questions weren’t lazy. Deebo has every right to be frustrated. The real problem is what happened next. #49ers https://t.co/zNq18IvLFy

WATCH: @ZachGelb calls interview with Deebo Samuel “an absolute joke” after it was cut short by the 49ers receiver. https://t.co/zVPWZMUjge https://t.co/NroWF1dn8w

RT @LWOSPatSheehan: The @MiamiDolphins have a golden opportunity to utilize the wildcat formation this season! Hear why they should and wha…

There%27s nothing wrong with getting frustrated during an interview and wanting it to be over. How you end things, however, makes all the difference in the world. #49ers #DeeboSamuel https://t.co/bfMILy0sFZ

RT @NFL_DovKleiman: Update: #49ers WR Deebo Samuel quits mid-interview amid questions about the #Eagles Deebo was on the @CBSSportsRadio w…

RT @LWOSPatSheehan: The @MiamiDolphins have a golden opportunity to utilize the wildcat formation this season! Hear why they should and wha…

RT @JackHammer_NFL: Patrick Mahomes and Brock Purdy each averaged 8.1 yards per attempt during the 2022 regular season. Mahomes average ya…

I think Jalen Pitre @jalenpitre1 is going to play the role of Hufanga in the Texans defense. Demeco Ryans #texans #49ers #nfl loved to bring Hufanga @talanaohufanga on early downs. Heres some of the concepts https://t.co/1IeZXPvKnS https://t.co/52JcXcOEWo

RT @49er_edits: QB Brock Purdy in preseason gave us a taste of what was to come. He looked like college Brock to me. Some of the media said…

RT @CBSSportsRadio: 49ers WR Deebo Samuel hangs up on The @ZachGelb Show after being asked about his comments following the NFC Championshi…